Click Here to return To Results

 

Screening for von Hippel-Lindau Disease by DNA Polymorphism Analysis JAMA 267:1226-1231, Glenn,G.M.,et al, 1992 See this aricle in Pubmed Article Abstract DNA polymorphism analysis predicted nine disease gene carriers and 33 individuals with the wild-type(normal)allele among the 48 individuals at risk of developing VHL disease;the test was not informative in six individuals.All nine individuals predicted to carry the VHL gene had evidence of occult disease on clinical examination.There was no clinical evidence of VHL disease in 32 of 33 individuals predicted to carry the wild-type allele.DNA polymorphism analysis can identify individuals likely to carry the VHL disease gene among asymptomatic members of disease families.This technique serves to focus attention on those individuals who require periodic medical examination and may help to alleviate the morbidity and mortality associated with this disease.

Related Tags

(click to filter results - removes previous filter) DNA probes gene genetic linkage genetic neurologic disorders genetic screening molecular genetics RFLPs Von Hippel Lindau Von Hippel Lindau,carrier Von Hippel Lindau,screening protocol for

Click Here to return To Results